Influenza pathogenicity during pregnancy in women and animal models
Identifieur interne : 000025 ( 1968/Analysis ); précédent : 000024; suivant : 000026Influenza pathogenicity during pregnancy in women and animal models
Auteurs : Debby Van Riel [Allemagne, Pays-Bas] ; Hans-Willi Mittrücker [Allemagne] ; Geraldine Engels [Allemagne] ; Karin Klingel [Allemagne] ; Udo R. Markert [Allemagne] ; Gülsah Gabriel [Allemagne]Source :
- Seminars in Immunopathology [ 1863-2297 ] ; 2016.
Abstract
Pregnant women are at the highest risk to develop severe and even fatal influenza. The high vulnerability of women against influenza A virus infections during pregnancy was repeatedly highlighted during influenza pandemics including the pandemic of this century. In 2009, mortality rates were particularly high among otherwise healthy pregnant women. However, our current understanding of the molecular mechanisms involved in severe disease development during pregnancy is still very limited. In this review, we summarize the knowledge on the clinical observations in influenza A virus-infected pregnant women. In addition, knowledge obtained from few existing experimental infections in pregnant animal models is discussed. Since clinical data do not provide in-depth information on the pathogenesis of severe influenza during pregnancy, adequate animal models are urgently required that mimic clinical findings. Studies in pregnant animal models will allow the dissection of involved molecular disease pathways that are key to improve patient management and care.
Url:
DOI: 10.1007/s00281-016-0580-2
PubMed: 27387428
PubMed Central: 7101682
Affiliations:
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PMC:7101682Le document en format XML
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The high vulnerability of women against influenza A virus infections during pregnancy was repeatedly highlighted during influenza pandemics including the pandemic of this century. In 2009, mortality rates were particularly high among otherwise healthy pregnant women. However, our current understanding of the molecular mechanisms involved in severe disease development during pregnancy is still very limited. In this review, we summarize the knowledge on the clinical observations in influenza A virus-infected pregnant women. In addition, knowledge obtained from few existing experimental infections in pregnant animal models is discussed. Since clinical data do not provide in-depth information on the pathogenesis of severe influenza during pregnancy, adequate animal models are urgently required that mimic clinical findings. Studies in pregnant animal models will allow the dissection of involved molecular disease pathways that are key to improve patient management and care.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD Van Kerkhove</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiore, Ae" uniqKey="Fiore A">AE Fiore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arck, Pc" uniqKey="Arck P">PC Arck</name></author><author><name sortKey="Hecher, K" uniqKey="Hecher K">K Hecher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabriel, G" uniqKey="Gabriel G">G 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Markowska-Daniel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwit, K" uniqKey="Kwit K">K Kwit</name></author><author><name sortKey="Pomorska Mol, M" uniqKey="Pomorska Mol M">M Pomorska-Mol</name></author><author><name sortKey="Markowska Daniel, I" uniqKey="Markowska Daniel I">I Markowska-Daniel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallace, Gd" uniqKey="Wallace G">GD Wallace</name></author><author><name sortKey="Elm, Jl" uniqKey="Elm J">JL Elm</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name></noRegion><name sortKey="Engels, Geraldine" sort="Engels, Geraldine" uniqKey="Engels G" first="Geraldine" last="Engels">Geraldine Engels</name><name sortKey="Engels, Geraldine" sort="Engels, Geraldine" uniqKey="Engels G" first="Geraldine" last="Engels">Geraldine Engels</name><name sortKey="Gabriel, Gulsah" sort="Gabriel, Gulsah" uniqKey="Gabriel G" first="Gülsah" last="Gabriel">Gülsah Gabriel</name><name sortKey="Gabriel, Gulsah" sort="Gabriel, Gulsah" uniqKey="Gabriel G" first="Gülsah" last="Gabriel">Gülsah Gabriel</name><name sortKey="Klingel, Karin" sort="Klingel, Karin" uniqKey="Klingel K" first="Karin" last="Klingel">Karin Klingel</name><name sortKey="Markert, Udo R" sort="Markert, Udo R" uniqKey="Markert U" first="Udo R." last="Markert">Udo R. Markert</name><name sortKey="Mittrucker, Hans Willi" sort="Mittrucker, Hans Willi" uniqKey="Mittrucker H" first="Hans-Willi" last="Mittrücker">Hans-Willi Mittrücker</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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